Genome integrity analysis technical note

Innovative method for genome integrity analysis of adeno-associated viruses (AAV)

Request more information on this novel methodology

It is crucial to accurately assess the quality and the correct length/size of the genome encapsulated in a capsid, as this affects the safety and efficacy of the gene therapy. Current methods are time-consuming and do not provide the needed resolution to accurately detect impurities.

SCIEX has developed a method capable of detecting intact and partial AAV genome as well as small size impurities, that provides:

  • Excellent separation resolution between intact and partial AAV genomes from small size impurities
  • Sample separation within 15 minutes
  • A comprehensive workflow for multiple AAV serotypes that provides a more definitive result than existing methods

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